ea0037ep253 | Calcium and Vitamin D metabolism | ECE2015
de Lloyd Anna
, Muller Ilaria
, Dodd Alan
, Durrant Hilary
, Pettit Rebecca
, Darlington Sarah
, Zhang Lei
, Evans Carol
, Rees Aled
, Ludgate Marian
The role of the thyrotropin receptor (TSHR) in bone is unclear. TSHR-deficient mice have low bone mineral density (BMD) and focal osteosclerosis despite normal thyroid hormones (suggesting TSHR function, in bone, is important). Subclinical hypothyroidism (SH) has various aetiologies including thyroid autoimmunity (TA) and inactivating TSHR mutations (TSHR-M). In TSHR-deficiency & TSH-M elevated TSH compensates for reduced TSHR function, whereas in TA it compensates for red...